David W. Maughan, Ph.D.
Research Professor

Background

• B.S., Physics, Washington State Univ., Pullman, Washington, 1964.
• Ph.D., Physiology/Biophysics, Univ. of Washington, Seattle, Washington, 1971.
• Postdoctoral: Physiology Institute, Univ. of Bern, Bern, Switzerland, 1971-1974.
• Established Investigator of the American Heart Association, 1979-1984.
• UVM Faculty since 1974.

Service

• UVM Faculty Senate Committee on Research and Development.
• Teaching: Physiology and Biophysics (CNS, Muscle regulation, Special Topics)
• Co-Chair, Contractility Subgroup of the Biophysical Society
• Chair, Organizing Committee, 5th International Muscle Energetics Conference
• NSF Cell Physiology Advisory Panel
• NIH program project review panel
• AHA Review Study Committee and Special Panel
• External reviewer, University of Kuwait, Department of Physiology
  

Current Research Support

• NIH R01 HL68034 Maughan (PI) 8/1/01-7/31/05
  “Do light chain extensions enhance muscle power output?”
  This study examines the structural and functional role of the myosin light chain extensions in mouse myocardium and fly direct flight muscle fibers.
  Role: PI
• NIH R01 AG19564 Maughan (PI) 9/30/00-8/31/04
  "Molecular basis of diabetic cardiomyopathy"
  This study examines the extent to which connective tissue proliferation, protein cross-linking via glycated end products, and tissue damage by reactive oxygen species contribute to changes in myocardial performance in diabetic patients.
  Role: PI
• NIH P01 HL59408-01A1 Warshaw (PI) 2/18/99-1/31/04
  “Sarcomere function of FHC mutant proteins.”
  This unit of a program project on a mouse model of familial hypertrophic cardiomyopathy focuses on changes in mechanical and biochemical performance of skinned strips and isolated hearts produced by structural modifications of muscle proteins.
  Role: PI, Unit 1.
• NIH R01 GM032443-17 Bernstein (PI) 7/1/83-3/31/04
  “Genetics and molecular biology of myosin”
  This study examines the genetics and molecular biology of Drosophila myosin, focusing on structure-function relationships.
  Role: Co-investigator
  
• NIH R01 AR43396 Bernstein (PI) 7/1/01-6/30/05
  "Myosin hinge region in contraction"
  This study examines the relationship between the Drosophila myosin heavy chain hinge region and its role in myofibril assembly and flight muscle function.
  Role: Co-investigator
  
• NIH R13 AR47917 Maughan (PI) 7/1/01- 6/30/02
  "Fifth International Conference on Muscle Energetics"
  The aim of this conference is to bring together scientists interested in presenting and discussing their recent contributions to the field of muscle energetics, especially in relation to the molecular basis of human diseases.
  Role: PI
  
• NSF MCB-9728868 Vigoreaux (PI) 7/1/01-6/30/03
  “Functional studies of flightin, a thick filament protein of Drosophila flight muscles.”
  This study examines the role of the flightin molecule in flight muscle ultrastructure and function in Drosophila.
  Role: Co-investigator
  

Recent lab publications