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David
Maughan, Ph.D.
 Since
1975, I have enjoyed developing an integrated program
in muscle biophysics that has as its central theme the
molecular and cellular basis for power output. Through
excellent collaborations with other research laboratories,
we have made use of a variety of genetic approaches to
probe contractile protein structure and function. Members
of our laboratory have been instrumental in advancing
a number of functional assays in muscle research, including
biomaterial analysis through application of small amplitude
length perturbations, small-angle X-ray diffraction, and
atomic force microscopy.
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ph: 802-656-4041
fax: 802-656-0747
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Brad Palmer, Ph.D.
 I
am interested in studying modifiers of heart muscle performance.
Our understanding of specific modifiers, such as protein
mutations, structural modifications, adrenergic stimulation,
and substrate availability, supplements our general understanding
of what makes a heart healthy or diseased. Using mechanical
perturbation techniques, we focus on characterizing the
effects of cardiac protein mutations, such as those found
in the familial hypertrophic cardiomyopathy, diabetes, and
exercise training. My goal is to predict the effects of
cardiac protein modifications on heart muscle performance.
ph: 802-656-2650
fax: 802-656-0747
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email: palmer@physiology.med.uvm.edu
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| Mark
Miller, Ph.D.
 I
am currently involved with investigating the possible
functional roles of the myosin S-2 hinge region (using
flight muscle from Drosophila melanogaster) and the effect
of myosin essential light chains on muscle performance
(using cardiac muscle from mice). I am using primarily
sinusoidal analysis, or small amplitude length perturbations,
to elucidate single muscle fiber properties along with
other measures such as flight tests and wing beat frequency
analysis. In addition, I am helping to develop new equipment,
a myofibrillar rig for instance, for use in the Maughan
lab.
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ph: 802-656-4861
fax: 802-656-0747
email: mmiller@emba.uvm.edu |
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| Bill
Barnes, M.S.
 I
joined the Maughan Lab in 1995 as a technical staff member.
My specialties include technical aspects of experimental
design and chemistry; electronic and mechanical systems;
custom computer programming, and data processing.
ph: 802-656-8879
fax: 802-656-0747
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Richard
Lachapelle, B.S.
 I
joined the Maughan and LeWinter Labs in 2000. I provide
support for the muscle mechanics studies of human cardiac
and skeletal skinned muscle strips. My specialties include
design, development, testing, calibration and maintenance
of research equipment.
ph: 802-656-8879
fax: 802-656-0747
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email: lachapel@physiology.med.uvm.edu
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Yuan
Wang, M.S.
 As
a lab technician, I joined the Maughan lab in 2001. I
provide technical support to study the relationship between
structure and function of muscle proteins responsible
for generating and regulating muscle contraction. My specialties
include chemistry, performing experimental and data analysis.
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ph: 802-656-8879
fax: 802-656-0747
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Joan
Braddock, B.S.
 I
joined the Maughan Lab in 2002 as a lab technician to
provide technical support in the study of the relationship
of certain diseases to heart muscle function. This includes
performing sinusoidal analysis using mechanical perturbation
techniques on muscle preparations from Drosophila, mice,
and humans. My specialties include preparing chemical
solutions, performing experimental protocols, data analysis,
and curve fitting with IDL.
ph: 802-656-8879
fax: 802-656-0747
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email: jbraddoc@physiology.med.uvm.edu
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Lori
Nyland, M.S.
 I
joined the Maughan lab as a graduate student in 1995,
and completed my M.S. degree in Biomedical Engineering
in 1998. As part of my research thesis I conducted atomic
force microscopy (AFM) on Drosophila flight muscle myofibrils
to characterize the morphology and stiffness of Drosophila
IFM myofibrils. Currently I am using AFM to look at thick
filament structure and stiffness in genetically-altered
Drosophila IFM.
ph: 802-656-4146
fax: 802-656-0747
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