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The molecular basis of muscle contraction publications

Visit Vermont Molecular Motors at the University of Vermont.

Recent publications (last 5 years):

Insect flight muscle

  • Barton B, Ayer G, Heymann N, Maughan DW, Lehmann F-O, Vigoreaux JO (2005) Flight muscle properties and aerodynamic performance of Drosophila expressing a flightin transgene. J. Exp. Biol. 208, 549-560.
  • Dickinson M, Farman G, Frye M, Bekyarova T, Gore D, Maughan D, Irving T (2005) Molecular dynamics of cyclically contracting insect flight muscle in vivo. Nature 433, 330-333.
  • Liu H, Miller MS, Swank DM, Kronert WS, Maughan DW, Bernstein SI (2005) Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster. PNAS 102(30), 10522-10525.
  • Maughan D, Vigoreaux J. (2005) Nature’s strategy for optimizing power generation in insect flight muscle, in: Sliding filament mechanism in muscle contraction: Fifty years of research, ed. H. Sugi, Ad. Exp. Med. Biol. 565, 157-167.
  • Maughan D, Swank D (2005) Insect flight muscle chemomechanics, in: Nature’s Versatile Engine: Insect Flight Muscle Inside and Out, ed. J. Vigoreaux, Springer-Verlag, Boston, 251-269.
  • Dickinson M, Farman G, Frye M, Bekyarova T, Gore D, Maughan D, Irving T (2005) Molecular dynamics of cyclically contracting insect flight muscle in vivo. Nature 433, 330-333.
  • Henkin JA, Maughan DW, Vigoreaux JO (2004) Mutations that affect flightin expression in Drosophila alter the viscolelastic properties of flight muscle fibers. Am. J. Physiol. Cell Physiol. 286, C65-C72.
  • Swank DM, Kronert WA, Bernstein SI, Maughan DW (2004) Alternative N-terminal regions of Drosophila myosin heavy chain tune muscle kinetics for optimal power output. Biophys. J. 87, 1805-1814.
  • Henkin JA, Maughan DW, Vigoreaux JO (2003) Mutations that affect flightin expression in Drosophila alter the viscolelastic properties of flight muscle fibers. Am. J. Physiol. Cell Physiol. 286, C65-C72.
  • Swank DM, Knowles AF, Suggs J, Sarsoza F, Lee A, Maughan D, Bernstein S (2002) The myosin converter domain modulates muscle performance. Nature Cell Biol. 4(4), 312-316. DOI: 10.1038/ncb/776.
  • Irving T, Bhattacharya S, Tesic I, Moore J, Simcox A, Vigoreaux J, Maughan D (2001) Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. J. Mus. Res. Cell Motil. 22(8), 675-683.
  • Irving TC, Maughan DW (2001) Real-time X-ray studies of living muscle. Ad. Photon Source Res. 4, 29-33.
  • Irving T, Bhattacharya S, Tesic I, Moore J, Simcox A, Vigoreaux J, Maughan D (2001) Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. J. Mus. Res. Cell Motil. 22(8), 675-683.
  • Moore JR, Dickinson MH, Vigoreaux JO, Maughan DW (2000) The effect of removing the N-terminal extension of the Drosophila myosin regulatory light chain upon flight ability and the contractile dynamics of indirect flight muscle. Biophys. J., 78(3), 1431-1440.
  • Vigoreaux JO, Moore JR, Maughan DW (2000) Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. Elastic Filaments of the Cell, Ed. Pollack G, Granzier H. Kluwer Academic/Plenum Publishers, 237-250.
  • Nyland L, Maughan D (2000) Morphology and transverse stiffness of Drosophila myofibrils measured by atomic force microscopy. Biophys. J., 78(3), 1490-1497
  • Irving TC, Maughan DW (2000) In vivo X-ray diffraction of indirect flight muscle from Drosophila melanogaster, Biophys. J. 78(5), 2511-2515

Vertebrate striated muscle

Human (heart research)

  • Maughan D (2005) Kinetics and energetics of the crossbridge cycle, in: Heart Failure Reviews, ed. M LeWinter, P VanBuren. Heart Failure Reviews 10, 175-185.
  • Fukagawa NK, Palmer BM, Barnes WD, Leavitt BJ, Ittleman FP, LeWinter MM, Maughan DW (2005) Acto-myosin crossbridge kinetics in humans with coronary artery disease: Influence of sex and diabetes mellitus. J. Mol. Cell. Cardiol. 39(5), 743-753.
  • Mulieri LA, Barnes W, Leavitt B, Ittleman F, LeWinter M, Maughan D (2002) Alterations of myocardial dynamic stiffness implicating abnormal cross-bridge function in human mitral regurgitation heart failure. Circ. Res. 90(1), 66-72.

Rabbit (proteomics)

  • Maughan DW, Henkin JA, Vigoreaux JO (2005) Concentrations of glycolytic enzymes and other cytosolic proteins in the diffusible fraction of a vertebrate muscle proteome. J. Cell. Mol. Proteomics 4, 1541-1549.

Rat (animal model of acquired disease)

  • McCurdy DT, Palmer BM, Maughan DW, LeWinter MM (2001) Myocardial cross-bridge kinetics in transition to failure in Dahl salt-sensitive rats. Am J Physiol Heart Circ Physiol. 281(3), H1390-6

Mouse (animal model of inherited diseases)

  • Miller MS, Palmer BM, Ruch S, Martin LA, Farman GP, Wang Y, Robbins J, Irving RC, Maughan DW (2005) The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle. J. Biol. Chem. 280 (41), 34427-34434.
  • Palmer BM, Georgakopoulos D, Jannsen PM, Wang Y, Alpert NR, Belardi DF, Harris SP, Moss RL, Burgon PG, Seidman CE, Seidman JG, Maughan DW, Kass DA (2004) Role of cardiac myosin binding protein C in sustaining left ventricular systolic stiffening. Circ. Res. 94, 1249-1255.
  • Palmer BM, Fishbaugher DE, Schmitt JP, Wang Y, Alpert NR, Seidman CE, Seidman JG, VanBuren P, Maughan DW (2004) Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium. Am. J. Physiol. Heart Circ. Physiol. 287, H91-H99.
  • Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW (2004) Reduced crossbridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C mice. Mol. Cell. Biochem., 263, 73-80.
  • Palmer BM, Noguchi T, Yang Y, Heim JR, Alpert NR, Burgon PG, Seidman CE, Seidman JG, Maughan DW, LeWinter MM (2004) Effect of Cardiac Myosin Binding Protein-C on mechanoenergetics in mouse myocardium. Circ. Res. 94, 1615-1622

Frog (cytosol)

  • Maughan DW, Godt RE (2001) Protein osmotic pressure and the state of water in frog myoplasm. Biophys. J. 80, 435-442