A postdoctoral position is open for the development of image processing methods for 3D reconstruction of heterogeneous single particles from electron micrographs. A good background in mathematics and experience in the development of algorithms required. There are several main aspects that make this project exciting: Images of macromolecular samples obtained under low-dose conditions in the electron microscope are extremely noisy when compared to many other image analysis problems. This creates challenges for image processing that require highly innovative and creative solutions. The methods we are developing for the 3D structure determination of heterogeneous populations of macromolecules will open new possibilities to analyze more complex biological samples. All developments will be carried out in close connection with the determination of the structure and function of biological macromolecular assemblies. An interest in biological problems is highly desirable, since understanding the biological implication of the new results that can be achieved with new methods is another important aspect that makes this project exciting. An example of a heterogeneous sample are the image data of complex I (s. research section). The aim of the the developments is the creation of more effective algorithms to analyze this type of sample.
We seek motivated individuals that can think independently and work cooperatively with biologists to carry out structural studies using electron microscopy and image processing techniques.
Candidates should preferably hold a Ph. D. in Biophysics, Physics, Material Science, Computer science or an appropriately related field. Experience in at least some aspects of structural biology, preferably 3D electron microscopy is highly desired.
Working knowledge of algorithm development, programming experience in any of the major programming languages (C, C++, Fortran, etc.) required.
If you are interested in this position, please contact me via e-mail with a brief description of your interests and your relevant work experience, a detailed resume and the names of three references. If you have any questions please contact me to discuss the potential for being a member of my lab and a member of the Structural Biology Community at UVM.
There are always opportunities for graduate research projects. If you are interested in a PhD project in our group, you can either pursue this through the interdisciplinary PhD program at the Computer Science Department here at UVM or by applying to the graduate program of the Dept. of Molecular Physiology and Biophysics (see Biophysics track). If you participating in any other PhD program at UVM, and are interested in our work, please come and discuss it with us.
Other Postdoctoral Positions: If you are interested to join our laboratory, always ask, as this web site may not be up to date. Sometimes we can support fellowship applications, and help guide you to different sources. Postdoctoral candidates we are looking for should have experience in any combination of two of the fields: electron microscopy, image processing and biochemistry.
Please contact
by email: (mraderma@uvm.edu)
or
by mail:
Dr.
Michael Radermacher
University of Vermont
Dept. Mol. Physiol. &
Biophysics
HSRF Bldg., Room 120
149 Beaumont Avenue
Burlington,
VT 05405 U.S.A.