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- Halpern, W., M.J. Mulvany and D.M. Warshaw. Mechanical properties of smooth muscle cells in the walls of arterial resistance vessels. J. Physiol. 275:85-101, 1978.
- Warshaw, D.M., M.J. Mulvany and W. Halpern.
Mechanical and morphological properties of
arterial resistance vessels in young and old
spontaneously hypertensive rats. Circ. Res.
45:250-259, 1979.
- Mulvany, M.J. and D.M. Warshaw. The active
tension-length curve of vascular smooth muscle
related to its cellular components. J. Gen.
Physiol. 74:85-104, 1979.
- Frink, R., P.P. Krupp, D.T. Root and D.M.
Warshaw. Effects of blood pressure reduction on
the ultrastructure of the adrenal cortex of the
spontaneously hypertensive rat. Exp. Cell. Biol.
48:245-254, 1980.
- Warshaw, D.M., D.T. Root and W. Halpern. Effects
of antihypertensive drug therapy on the
morphology and mechanics of resistance arteries
from spontaneously hypertensive rats. Blood
Vessels 17:257-270, 1980.
- Mulvany, M.J. and D.M. Warshaw. The anatomic
location for the series elastic component in a
vascular smooth muscle. J. Physiol. 314:321-330,
1981.
- Warshaw, D.M. and F.S. Fay. Tension transients in
single isolated smooth muscle cells. Science
219:1438-1441, 1983.
- Warshaw, D.M. and F.S. Fay. Cross-bridge
elasticity in single smooth muscle cells. J. Gen.
Physiol. 82:157-199, 1983.
- Warshaw, D.M., J.L. Szarek, M.S. Hubbard and J.N.
Evans. Pharmacology and force development of
single freshly isolated bovine carotid artery
smooth muscle cells. Circ. Res. 58:399-406,
1986.
- Warshaw, D.M., W. McBride and M.S. Hubbard.
Calcium and MgATP2- dependence of shortening in
skinned single smooth muscle cells. Am. J.
Physiol. Cell:21:418-427, 1987.
- Warshaw, D.M. Force:velocity relationship in
single isolated toad stomach smooth muscle cells.
J. Gen. Physiol. 89:771-789, 1987.
- Warshaw, D.M., W.J. McBride and S. Work.
Corkscrew-like shortening in single smooth muscle
cells. Science 236:1457-1459, 1987.
- Warshaw, D.M., S. Work and W.J. McBride. Effect
of low extracellular calcium on shortening
velocity in isolated single smooth muscle cells.
Pflugers Arch. 410:185-191, 1987.
- Warshaw, D.M., D.D. Rees and F.S. Fay.
Characterization of crossbridge elasticity and
kinetics of crossbridge cycling during force
development in single smooth muscle cells. J.
Gen. Physiol. 91:761-779, 1988.
- Work, S.S. and D.M. Warshaw. Detection of surface
movements in smooth muscle cells: Digital video
microscopy. Computers in Biol. and Med.
18:385-393, 1988.
- Absher, M., J. Woodcock-Mitchell, J. Mitchell, L.
Baldor, R. Low and D.M. Warshaw. Characterization
of vascular smooth muscle cell phenotype in
long-term culture. In Vitro 25:183-192,
1989.
- Wu, J., D., Gonghoan, S.S. Work, and D.M.
Warshaw. Acoustic radiation pressure on a rigid
cylinder: an analytical theory and experiments.
J. Acoust. Soc. Am. 87:581-586, 1990.
- Yamakawa, M., D.E. Harris, F.S. Fay, and D.M.
Warshaw. Mechanical transients of single toad
stomach smooth muscle cells: effects of lowering
temperature and extracellular calcium. J. Gen. Physiol.
95:697-715, 1990.
- Warshaw, D.M., J.M. Desrosiers, S.S. Work and K.M
Trybus. Smooth muscle myosin cross-bridge
interactions modulate actin filament sliding
velocity in vitro. J.
Cell Biol. 111: 453-463, 1990
- Harris, D.E. and D.M. Warshaw. Slowing of velocity during isotonic shortening in single isolated smooth muscle cells - evidence for an internal load. J. Gen. Physiol. 96:581-601, 1990.
- Harris, D.E. and D.M. Warshaw. Length vs. active
force relationship in single isolated smooth
muscle cells. Am. J.
Physiol. 260:C1104-C1112, 1991.
- Warshaw, D.M., J.M. Desrosiers, S.S. Work and
K.M. Trybus. Effects of MgATP, MgADP, and Pi on
actin movement by smooth muscle myosin. J.
Biol. Chem. 266:24339-24343, 1991.
- Work, S.S. and D.M. Warshaw. Computer-assisted
tracking of actin filament motility. Anal.
Bioch. 202:275-285, 1992.
- Harris, D.E., D.M. Warshaw, and M. Periasamy.
Nucleotide sequences of the rabbit
à-smooth-muscle and ?-non-muscle actin
mRNAs. Gene 112:265-266, 1992.
- Haeberle, J.R., K.M. Trybus, M.E. Hemric, and
D.M. Warshaw. The effects of smooth muscle
caldesmon on actin filament motility. J.
Biol. Chem. 267:23001-23006,
1992.
- Harris, D.E. and D.M. Warshaw. Smooth and
skeletal muscle actin are mechanically
indistinguishable in the in vitro motility assay.
Circ. Res. 72:219-224, 1993.
- Harris, D.E. and D.M. Warshaw. Smooth and
skeletal muscle myosin both exhibit low duty
cycles at zero load in vitro. J.
Biol. Chem. 268:14764-14768, 1993.
- Solaro, R.J., G. Gambassi, D.M. Warshaw, M.R.
Keller, H.A. Spurgeon, N. Beier, and E.G.
Lakatta. Stereoselective actions of
thiadiazinones on canine cardiac myocytes and
myofilaments. Circ. Res. 73:981-990, 1993.
- VanBuren, P., S.S. Work, and D.M. Warshaw.
Enhanced force generation by smooth muscle myosin
in vitro. PNAS
91:202-205, 1994.
- Harris, D.E., S.S. Work, R.K. Wright, N.R. Alpert
and D.M. Warshaw. Smooth, cardiac, and skeletal
muscle myosin force and motion generation
assessed by cross-bridge mechanical interactions
in vitro. J.
Musc. Res. Cell Motil. 15:11-19, 1994.
- Siegman, M.J., S.U. Mooers, T.B. Warren, D.M.
Warshaw, M. Ikebe, and T.M. Butler. Comparison of
the effects of 2,3-butanedione monoxime on force
production, myosin light chain phosphorylation
and chemical energy usage in intact and
permeabilized smoo th and skeletal muscles. J.
Musc. Res. Cell Motil. 15:457-472,
1994.
- VanBuren, P., G.S. Waller, D.E. Harris, K.M.
Trybus, D.M. Warshaw and S. Lowey. The essential
light chain is required for full force production
by skeletal muscle myosin. PNAS
91:12403-12407, 1994.
- VanBuren, P., D.E. Harris, N.R. Alpert, and D.M.
Warshaw. Cardiac V1 and V3 myosins differ in
their hydrolytic and mechanical activities in
vitro. Circ. Res. 77:439-444, 1995.
- Harris, D.E., C.J. Stronski, E. Hayes, and D.M. Warshaw. Thiophosphorylation independently activates each head of smooth muscle myosin in vitro. Am.
J. Physiol. (Cell) 269:C1160-C1166,
1995.
- Warshaw, D.M. The in vitro motility assay: A
window into the myosin molecular motor. News in
Physiol. Sci. 11:1-7, 1996.
- Nguyen, T.-T., E. Hayes, L.A. Mulieri, B.J.
Leavitt, H.E.D.J. terKeurs, N.R. Alpert, and D.M.
Warshaw. Maximal actomyosin ATPase activite and
in vitro myosin motility are unaltered in human
mitral regurgitation heart failure. Circ. Res.
79:222-226, 1996.
- Sollot, S.J., B.D. Ziman, D.M. Warshaw, H.A.
Spurgeon, and E.G. Lakatta. Actomyosin
interaction modulates the resting length of
unstimulated cardiac ventricular cells. Am. J.
Physiol. 271:(Heart Circ.
Physiol.40):H896-H905, 1996.
- Dupuis, D.E., W.H. Guilford, J. Wu, and D.M. Warshaw. Actin filament mechanics in the laser trap. J.
Musc. Res. Cell Motil. 18:17-30, 1997.
- Guilford, W.H., D.E. Dupuis, G. Kennedy, J. Wu,
J.B. Patlak and D.M. Warshaw. Smooth and skeletal
muscle myosins produce similar unitary forces and
displacements in the laser trap. Biophys. J.
72:1006-1021, 1997. New and Notable: Molloy, J.E.
and D.C.S. White. Smooth and skeletal muscle
single-molecule mechanical experiments. Biophys. J.
72:984-986, 1997.
- (New and Notable: Molloy, Justin E. and David C.S. White. Smooth and skeletal muscle single-molecule mechanical experiments. Biophys. J. 72:984-986, 1997).
- Warshaw, D.M., E. Hayes, D. Gaffney, A.-M., Lauzon, J. Wu, G. Kennedy, K. Trybus, S. Lowey and C. Berger. Myosin conformational states determined by single fluorophore polarization. PNAS 95:
8034-8039, 1998.
- Guilford, W.H. and D.M. Warshaw. The molecular
mechanics of smooth muscle myosin. Comp. Biochem.
& Physiol. Part B, 119:451-458, 1998.
- Fewell, J., T.E. Hewitt, R. Kelvitsky, E. Hayes,
D.M. Warshaw, A. Sanbe, D. Maughan and J.
Robbins. Functional significance of cardiac
myosin essential light chain isoform switching in
transgenic mice. J. Clin. Inv.
101:2630-2639, 1998.
- Lauzon, A.M., K.M. Trybus and D.M. Warshaw. Molecular mechanics of two smooth muscle heavy meromyosin constructs that differ by an insert in the motor domain. Acta Physiol. Scand. 164: 357-361, 1998.
- Lauzon, A.M., M.J. Tyska, A.S. Rovner, Y. Freyzon, D.M. Warshaw, and K.M. Trybus. A 7-amino acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin inthe laser trap. J. Musc. Res. Cell Motil 19:825-837, 1998.
- VanBuren, P., K. Begin, and D.M. Warshaw.
Fluorescent phalloidin enables visualization of
actin without effects on myosin's actin filament
sliding velocity and hydrolytic properties in
vitro. J. Mol. Cell. Cardiol. 30:2777-2783,
1998.
- Tyska, M.J., D.E. Dupuis, W.H. Guilford, J.B.
Patlak, G.S. Waller, K.M. Trybus, D.M. Warshaw
and S. Lowey. Two heads of myosin are better than
one for generating force and motion. PNAS
96:4402-4407, 1999.
- Palmiter, K.A., M.J. Tyska, D.E. Dupuis, N.R.
Alpert and D.M. Warshaw. Kinetic
differences at the single molecule level account
for the functional diversity of rabbit cardiac
myosin isoforms. J. Physiol.
519(3): 669-678, 1999.
- VanBuren, P., Palmiter, K.A., and D.M.
Warshaw. Tropomyosin directly modulates
actomyosin mechanical performance at the level of
a single actin filament. Proc. Natl. Acad.
Sci. USA 96: 12488-12493, 1999.
- Tyska, M.J., Hayes, E., Giewat, M.,
Seidman, C.E., Seidman, J.G. and D.M.
Warshaw. Single molecule mechanics of R403Q
mutant cardiac myosin isolated from the mouse
model of familial hypertrophic cardiomyopathy.
Circ Res. 86:737-744, 2000. (Editorial
Comment: Moss, Richard L. and Jose
SantAna Periera. Enhanced Myosin
Function due to a Point Mutation Causing a
Familial Hypertrophic Cardiomyopathy. Circ.
Res. 86:720-722, 2000).
- (Editorial Comment: Moss, Richard L. and Jose SantAna Periera. Enhanced Myosin Function due to a Point Mutation Causing a Familial Hypertrophic Cardiomyopathy. Circ. Res. 86:720-722, 2000).
- Sanbe, A., Gulick, J., Hayes, E., Warshaw, D.M., Osinska, H., Chan, C.-B., Klevitsky, R., and J. Robbins. Myosin light chain replacement in the heart. Am. J. Physiol. 279:H1355-H1364, 2000.
- Babu, G.J., Warshaw, D.M. and M. Periasamy.
Smooth muscle myosin heavy chain isoforms and
their role in muscle physiology. Microscopy
Res. & Techn. 50:532-540, 2000.
- Sanbe, A., Nelson, D., Gulick, J., Setser, E.,
Osinska, H., Wang, X., Hewett, T.E., Klevitsky,
R., Hayes, E., Warshaw, D.M. and J.
Robbins. In vivo analysis of an essential
myosin light chain mutation linked to familial
hypertrophic cardiomyopathy. Circ. Res.
87:296-302, 2000.
- Yamashita, H., Tyska, M.J., Warshaw, D.M., Lowey,
S. and Trybus, K.M. Functional consequences
of mutations in the smooth muscle myosin heavy
chain at sites implicated in familial
hypertrophic cardiomyopathy. J.
Biol. Chem. 275:28045-28052, 2000.
- Warshaw, D.M., Guilford, W.H., Freyzon, Y.,
Krementsova, E., Palmiter, K.A., Tyska, M.J. and
K.M Trybus. The light chain binding domain of
expressed smooth muscle heavy meromyosin acts as
a mechanical lever. J.
Biol. Chem. 275:37167-37172, 2000.
- Palmiter, K.A., Tyska, M.J., Haeberle, J.R.,
Alpert, N.R., Fananapazir, L., and D.M. Warshaw.
R403Q and L908V mutant b-cardiac myosin from
patients with familial hypertrophic
cardiomyopathy exhibit enhanced mechanical
performance at the single molecule level. J.
Musc. Res. Cell Motil. 21:609-620, 2000.
- Lauzon, A.M., Fagnant, P.M., Warshaw, D.M. and
K.M. Trybus. Coiled-coil unwinding at the smooth
muscle myosin head-rod junction is required for
optimal mechanical performance. Biophys. J.
80:1900-1904, 2001.
- Moore, J.R., E.B. Krementsova, K.M. Trybus and
D.M. Warshaw. Myosin V exhibits a high duty cycle
and large unitary displacement. J. Cell Biol.
155:4:625-635, 2001.
- Tyska, M.J and D.M. Warshaw. The myosin power
stroke. Cell
Motil. & Cytoskel. (in press), 2001.
- Baker, J.E., Brosseau, C., Joel, P.B., and D.M. Warshaw. The biochemical kinetics underlying actin movement generated by one and many skeletal muscle myosin molecules. Biophys. J. , p. 2134-2147, Vol. 82, No. 4, 2002.
- Alpert, N.R., Mulieri, and D.M. Warshaw. The failing human heart. Cardiovasc. Res., Apr;54(1):1-10, 2002.
- Alpert NR, Brosseau C, Federico A, Krenz M, Robbins J, Warshaw DM. Molecular mechanics of mouse cardiac myosin isoforms. Am J Physiol Heart Circ Physiol. Oct;283(4):H1446-54, 2002.
- Littlefield KP, Swank DM, Sanchez BM, Knowles AF, Warshaw DM, Bernstein SI. Abstract The converter domain modulates kinetic properties of Drosophila myosin. Am. J. Physiol. Cell Physiol. 2003 Apr;284(4):C1031-8. PMID: 12477668 [PubMed - indexed for MEDLINE]
- Krenz M, Sanbe A, Bouyer-Dalloz F, Gulick J, Klevitsky R, Hewett TE, Osinska HE, Lorenz JN, Brosseau C, Federico A, Alpert NR, Warshaw DM, Perryman MB, Helmke SM, Robbins J. Abstract Analysis of myosin heavy chain functionality in the heart. J. Biol. Chem. 2003 May 9;278(19):17466-74. PMID: 12626511 [PubMed - in process]
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Books, Chapters,
Symposium Proceedings (Not refereed):
- Warshaw, D.M. "Direct correlation between
structure and function in arterial resistance
vessels in young and old spontaneously
hypertensive rats." Doctoral Dissertation,
University of Vermont, October, 1978.
- Fay, F.S., D.D. Rees and D.M. Warshaw. The
Contractile Mechanism In Smooth Muscle. In:
"Membrane Structure and Function, Vol.
4." Ed. E.E. Bittar, John Wiley and Son, New
York, pp. 79-130, 1981.
- Warshaw, D.M. and F.S. Fay. Tension Transients in
Single Isolated Smooth Muscle Cells: Insight into
the Cross-Bridge Mechanism. In "Smooth
Muscle Contraction." Ed. N.L. Stehens,
Marcel-Dekker, Inc. New York, pp. 145-151,
1984.
- Warshaw, D.M. and F.S. Fay. Tension transients in
single isolated smooth muscle cells. In:
"Contractile Mechanisms in Muscle",
Advances in Experimental Medicine and Biology,
Vol. 170. Ed. G.H. Pollack and H. Sugi, Plenum
Press, New York, pp. 617-6 23, 1984.
- Warshaw, D.M., W. McBride and S. Work.
Force:velocity relationship and helical
shortening in single smooth muscle cells. In:
"Regulation and Contraction in Smooth
Muscle". Eds. M. Siegman, A. Somlyo, and N.
Stephens. Alan Liss, New York, pp. 303- 317,
1987.
- Absher, M.P., L. Baldor and D.M. Warshaw. Effects
of nitrendipine on growth activity in cultured
vascular smooth muscle cells. J.
Cardiovasc. Pharm. 12:S104-S106,
1988.
- Warshaw, D.M. Smooth muscle: Muscles and muscle
systems. Encyclopaedia Britannica pp. 472-473,
1989.
- Warshaw, D.M., M. Yamakawa and D. Harris.
Evidence for an internal load in single smooth
muscle cells. In: "Muscle Energetics".
Eds. R.J. Paul, G. Elzinga and K. Yamada. Alan
Liss, New York, pp. 329-345, 1989.
- Warshaw, D.M., J.M. Desrosiers, S.S. Work, and
K.M. Trybus. Mechanical interaction of smooth
muscle crossbridges modulates actin
filament velocity in vitro. In:
"Frontiers in Smooth Muscle Research".
Eds. N. Sperelakis and J.D. Wood. Alan Liss, N ew
York, pp. 815-826, 1990.
- Warshaw, D.M., and K.M. Trybus. In vitro evidence
for smooth muscle crossbridge mechanical
interactions. In: "Regulation of Smooth
Muscle Contraction." Ed. R. Moreland. Plenum
Press, New York, pp. 53-59, 1991.
- Holubarsch, Ch., V. Lombardi, H. Suga, and D.
Warshaw. Fourth International Workshop on Muscle
Energetics - A NATO Advanced Researc Workshop. J.
Muscle Res. Cell. Motil. 14:351-354, 1993.
- VanBuren, P., W.H. Guilford, G. Kennedy, J. Wu
and D. Warshaw. Smooth muscle myosin: a high
force-generating molecular motor. Biophys. J.
68:256s-259s, 1995.
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