 Education
- 1991 -
1994 Sheffield University Sheffield,
S.Yorks, UK
Biochemistry (Hons)
2:1
- 1994 -
1998 University of Bristol Bristol, Avon
BS8 2TY, UK
PhD: Probing the dynamic and
conformational properties of the
chaperonins GroEL and GroES.
~These highly cooperative multimeric
molecules communicate between subunits,
my aim was to characterise this
quantitatively. This characterisation was
on two levels: (i) the mechanistic
implications of nucleotide binding and
hydrolysis with respect to the overall
reaction cycle, (ii) the mechanism of
information transfer in a positive and
negatively cooperative manner.
Professional
Experience
- 2001-present
Postdoctoral Fellow Dept. Molec.
Physiology and Biophysics, University of
Vermont, Burlington, VT.
- 1998 -
2001 Postdoctoral research associate,
School. of Biochemistry and Molecular
Biology, University of Leeds Leeds, LS2
9JT, UK
~This project initially involved coercing
a monomeric protein to form fibrillar
structures in vitro, by altering
growth conditions. Following this, a
number of techniques were employed to
study the growth mechanism and
morphologies of these fibrils.
~ß2m can be made to
form two distinct morphological types
under different solution conditions.These
morphologies were studied using EM and
AFM and using growth rate profiles the
significance of these types was
investigated.
Exhibits
- 1995
Scientific Power to the People Exhibition
– Bristol, Avon.
Bristol Exploratory
- 1996, 97
The Galleries Shopping Centre
~ Designed and presented a stand to
present biochemical research to the
general public.
Teaching
Experience
- 1994-98
Demonstrating in undergraduate practical
classes.
- 1994-98
Undergraduate tutorials for first year
dual honours students.
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